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目的探讨大黄虫丸对大鼠肺纤维化形成阶段神经递质的干预作用。方法普通级Wistar大鼠36只,随机分为正常组、模型组、大黄虫丸组各12只,除正常组外,其余2组均采用气管内注入平阳霉素复制肺纤维化模型,大黄虫丸组灌胃浓度为80mg/ml药液1.5ml/100g体重,模型组灌胃等量蒸馏水,每天给药1次,各组于造模后第28天处死,比较各组大鼠肺、下丘脑及海马组织中多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)含量。结果模型组大鼠肺与下丘脑组织中NE、DA、5-HT及海马组织中5-HT含量均与正常组有统计学差异(P<0.05);大黄虫丸组肺、下丘脑NE、DA、5-HT含量及海马组织中NE、5-HT含量均与模型组有统计学差异(P<0.05)。结论肺纤维化形成阶段肺与下丘脑DA、NE、5-HT及海马组织中5-HT含量升高,大黄虫丸能调节肺纤维化模型大鼠肺及脑组织中NE、DA、5-HT的含量。
Objective To investigate the effect of Dahuang Zhechong pill on neurotransmitter in pulmonary fibrosis stage. Methods Thirty-six normal Wistar rats were randomly divided into normal group, model group and Dahurian group, 12 rats in each group. Except for the normal group, the rats in the other two groups were given Pingyangmycin for pulmonary fibrosis. The worm group was given intragastric administration of 1.5ml / 100g body weight at a concentration of 80mg / ml. The model group was orally administered with the same amount of distilled water once a day. Each group was sacrificed on the 28th day after the model was established. Hypothalamic and hippocampal tissue dopamine (DA), norepinephrine (NE), serotonin (5-HT) content. Results The content of 5-HT in NE, DA, 5-HT and hippocampus in lung and hypothalamus of rats in model group were significantly different from those in normal group (P <0.05). The contents of NE, DA, , The content of DA and 5-HT and the content of NE and 5-HT in hippocampus were significantly different from those in model group (P <0.05). CONCLUSION: The content of 5-HT in the lung and hypothalamus of DA, NE, 5-HT and hippocampus in the stage of pulmonary fibrosis is increased. Dahuang Zhechong pill can regulate the content of NE, DA, 5 -HT content.