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目的了解贵州省部分县健康人群麻疹Ig G抗体水平,为制定麻疹防控策略提供科学依据。方法采集10县10个乡(镇)8个年龄组<1岁~≥20岁人群血清标本2 552份,采用酶联免疫吸附法检测麻疹Ig G抗体。结果检测2 552份血标本,麻疹Ig G抗体阳性率为94.40%。8个年龄组中,<1岁组麻疹Ig G抗体阳性率最低,为82.24%,其余阳性率均高于93.29%。10个县中以威宁县的麻疹Ig G抗体阳性率最低,为79.92%,其余县阳性率均高于91.25%。未接种麻疹类疫苗和接种史不详的人群中麻疹Ig G抗体阳性率最低在<1岁组,接种1剂次以上疫苗后,麻疹Ig G阳性率高于95%,接种2剂次与3剂次麻疹类疫苗后阳性率差异无统计学意义(χ2=0.121,P=0.728)。结论加强健康人群麻疹Ig G抗体的监测,发现免疫薄弱地区和乡镇是消除麻疹的关键。
Objective To understand the level of measles IgE antibody in healthy population in some counties of Guizhou Province and provide a scientific basis for the development of measles prevention and control strategies. Methods A total of 2 552 serum samples of 8 age groups <10 years old and 10 years old from 10 townships (towns) of 10 counties were collected. The Ig G antibody of measles was detected by enzyme-linked immunosorbent assay. Results A total of 2 552 blood samples were detected. The positive rate of measles Ig G antibody was 94.40%. Among 8 age groups, the positive rate of measles IgG antibody was the lowest in <1 year old group, which was 82.24%, the other positive rates were higher than 93.29%. The positive rate of measles Ig G antibody in Weining County among 10 counties was the lowest (79.92%), the positive rates of the other counties were all higher than 91.25%. The lowest prevalence of measles Ig G antibody among those who did not receive the measles vaccine and the history of vaccination was lower than 1 year old. After vaccination for more than one dose, the positive rate of measles IgG was higher than 95% There was no significant difference in the positive rate of measles vaccine (χ2 = 0.121, P = 0.728). Conclusion To strengthen the monitoring of measles Ig G antibodies in healthy people, it is found that the key areas to eliminate measles are weak immunization areas and villages and towns.