Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and home

• 作 者: Akiko Suzuki Kenichi Ogata Hir
• 机 构: DepartmentofDiagnostic&,BiomedicalSciences,CenterforCraniofacialResearch,DivisionofTranslationalM
• 出 处: 骨研究:英文版
• 发表日期: 2020年1期
• 关键词: METABOLISM CHOLESTEROL HOMEOSTASIS
• 基金项目: the National Institute of Dental and Craniofacial Research,NIH(DE024759,DE026208,DE026509,and DE026767),to J.I.and UTHealth School of Dentistry faculty funds to J.I.

Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets. However, little is known about the precise roles of intracellular cholesterol metabolism