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目的探讨血液透析联合血液灌流在肾性贫血临床治疗上的应用效果。方法选取2010年7月—2015年6月来我院接受血液透析治疗且并发肾性贫血患者68例,按照双盲法随机分成2组,每组各34例,对照组予以血液透析联合常规药物治疗,研究组在对照组的基础上加用血液灌流治疗。治疗半年后,对比2组患者血红蛋白(Hb)、血细胞比容(Hct)、甲状旁腺素(PTH)以及C-反应蛋白(CRP)的变化情况。结果相较于对照组,研究组患者的Hb、Hct明显更高,组间对比具有显著差异(P<0.05);同时,研究组患者清除炎症递质及PTH效果明显优于对照组,组间对比均有显著差异(P<0.05)。结论血液透析联合血液灌流能够更好地改善肾性贫血患者贫血状况,具有良好的临床实用价值。
Objective To investigate the clinical effect of hemodialysis combined with hemoperfusion on renal anemia. Methods From July 2010 to June 2015, 68 patients with renal anemia who were treated by hemodialysis in our hospital were randomly divided into 2 groups according to double-blind method, 34 patients in each group. The control group was given hemodialysis combined with conventional drugs Treatment, the study group in the control group plus hemoperfusion treatment. After six months of treatment, the changes of hemoglobin, hematocrit, parathyroid hormone and C-reactive protein were compared between the two groups. Results Compared with the control group, Hb and Hct were significantly higher in the study group and there was significant difference between the two groups (P <0.05). At the same time, the study group was significantly better than the control group in clearing inflammatory mediators and PTH, There were significant differences (P <0.05). Conclusion Hemodialysis combined with hemoperfusion can better improve the anemia in patients with renal anemia, which has good clinical value.