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目的 :探讨老年脑梗塞 (CI)患者血浆与血小板神经肽Y(NPY)、神经降压素 (NT)含量的变化及临床意义。方法 :对 2 5例急性脑梗塞 (ACI)和 2 0例脑梗塞后遗症 (SCI)患者血浆与血小板提取液中NPY、NT含量进行特异性放免测定 ,并设正常对照组 ,对各种参数进行对比分析。结果 :ACI组血浆NPY增高 ,血浆NT降低 ,而血小板NPY降低 ,血小板NT升高 ,均与对照组有显著差异 (P <0 0 1) ,SCI组与ACI组对比 ,血浆与血小板NPY、NT水平接近对照组 ,但与对照组仍有差异 (P <0 0 1,P <0 0 5 )。ACI组血浆与血小板NPY水平呈反向改变。结论 :NPY、NT参与人类脑血管疾病的病理生理过程 ,不同病期血浆与血小板NPY、NT水平呈现不同的变化规律。从相关实验看出 ,CI患者血小板提取液和血浆中NPY关系十分密切 ,证实血浆中大量增加的NPY均来自血小板的释放。另从两组CI患者血浆与血小板NT含量变化来看 ,ACI组患者血浆NT含量明显低于对照组 ,并随病情好转 ,NT水平恢复正常 ,提示NT与预后有关。综上所述 ,我们认为对CI患者进行血浆和血小板NPY、NT水平检测 ,对进一步了解CI的发病机理、进行早期抗凝溶栓治疗、观察病情演变和判断预后均具有一定的实用价值。
Objective: To investigate the changes and clinical significance of neuropeptide Y (NPY) and neurotensin (NT) in plasma and platelet of elderly patients with cerebral infarction (CI). Methods: The radioimmunoassay was used to determine the contents of NPY and NT in plasma and platelet extract from 25 acute cerebral infarction (ACI) and 20 cerebral infarction sequelae (SCI) patients. The normal control group was set up and various parameters Comparative analysis. Results: Compared with ACI group, the plasma NPY and plasma NTY, the NPY of platelets and the NT of platelets in ACI group were significantly different (P <0.01) Level close to the control group, but still different from the control group (P <0.01, P <0 05). ACI plasma and platelet NPY levels were reversed. CONCLUSION: NPY and NT are involved in the pathophysiological process of human cerebrovascular diseases. The levels of NPY and NT in plasma and platelets show different changes at different stages. Relevant experiments show that, CI patients with platelet extract and plasma NPY relationship is very close, confirmed that a large number of plasma NPY are derived from platelets. In addition, the changes of NT in plasma and platelet of two groups of patients with CI showed that the plasma NT level in ACI group was significantly lower than that in control group, and with the improvement of disease, NT level returned to normal, suggesting that NT was associated with prognosis. In summary, we believe that detection of plasma and platelet NPY and NT levels in CI patients is of practical value for further understanding the pathogenesis of CI, early anticoagulation and thrombolytic therapy, and observation of the evolution and prognosis of CI.