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目的 探讨蝮蛇抗栓酶和川芎嗪联用对脑梗塞病人血液流变学指标的影响。方法 对81例经头颅CT确诊的急性脑梗塞病人,分别用蝮蛇抗栓酶(1U/次)、川芎嗪(200mg/次)以及二者联用[(0.5U+100mg)/次],观察其对血栓形成及全血表观粘度、血沉和红细胞压积等指标的影响 结果 三者对降低病人的全血表观粘度(高切、低切)、血栓长度、湿重与对照组相比均有显著性意义(P<0.01),川芎嗪对降低病人的血浆粘度无统计学上的显著意义。二者联用除对降低病人红细胞压积无统计学上的显著意义外,其它各项指标降低均达到正常水平。结论 蝮蛇抗栓酶组疗效优于川芎嗪组。两药联用对脑梗塞病人血液流变指标确有显著改善。
Objective To investigate the effect of combination of viper antithrombotics and ligustrazine on hemorheology in patients with cerebral infarction. Methods Eighty - one patients with acute cerebral infarction diagnosed by skull CT were divided into two groups according to their anti - thrombolysis (1U / time), ligustrazine (200mg / time) and the combination of [(0.5U + 100mg) / time] To observe the thrombosis and whole blood apparent viscosity, erythrocyte sedimentation rate and hematocrit and other indicators of the results of the three to reduce the patient’s whole blood apparent viscosity (high and low cut), thrombus length, wet weight and control group phase (P <0.01). Ligustrazine could not reduce the plasma viscosity of patients with statistical significance. In addition to the combination of the two to reduce the patient’s hematocrit no statistically significant, the other indicators were reduced to normal levels. Conclusion Viper antithrombotic group is better than ligustrazine group. Combination of two drugs for cerebral infarction in patients with blood rheology indicators indeed significantly improved.