论文部分内容阅读
研究了齐墩果醇酸（ＯＡ）对青霉噻唑（ＢＰＯ）蛋白致敏豚鼠过敏性休克的对抗作用。结果：豚鼠皮下注射ＯＡ，可明显降低ＢＰＯ－蛋白致敏豚鼠过敏性休克的发生率和死亡率，致敏对照组过敏性休克的发生率和死亡率均为１００％，ＯＡ５０，１００ｍｇ·ｋｇ－１·ｄ－１给药组过敏性休克发生率分别为７３％和６３％，死亡率分别为６３％和５５％；抑制致敏豚鼠血清抗ＢＰＯ抗体生成；降低肺组胺含量；抑制豚鼠ＰＣＡ反应及大鼠颅骨骨膜肥大细胞脱颗粒。提示：ＯＡ对抗青霉素过敏性休克作用机制与其抑制血清抗ＢＰＯ抗体生成，并降低组胺含量有关。
The antagonistic effect of oleanolic acid (OA) on allergic shock induced by penicillin (BPO) protein in guinea pigs was studied. Results: The guinea pig injected subcutaneously with OA could significantly reduce the incidence and mortality of anaphylactic shock induced by BPO-protein in guinea pigs. The incidence and mortality of anaphylactic shock were 100%, 100 mg · kg- The incidence of anaphylactic shock was 73% and 63% respectively in the 1 · d-1 group and the mortality rates were 63% and 55% respectively. The anti-BPO antibody was inhibited in the sensitized guinea pig, the histamine content in the lung was decreased, Response and degranulation of rat skull periosteal mast cells. Tip: OA against penicillin anaphylactic shock mechanism and its inhibition of serum anti-BPO antibody generation, and reduce the histamine content.