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[目的]了解糖尿病患者血清超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平。[方法]收集64例糖尿病无并发症患者、63例伴并发症患者及66例健康体检合格者的血浆;血浆乳胶增强免疫比浊法测定hs-CRP浓度、酶免化学发光法测定Hcy的浓度,酶法测定CHOL及TG的浓度。[结果]糖尿病无并发症组和伴并发症组血清hs-CRP、Hcy和CHOL及TG水平均高于正常对照组(P﹤0.01),伴并发症组血清hs-CRP和Hcy又高于无并发病组(P﹤0.05);相关性分析表明血清hs-CRP与CHOL和TG呈正相关,Hcy与各指标无相关性。[结论]hs-CRP和Hcy在预测糖尿病患者早期动脉粥样硬化有重要的临床意义,炎症反应可能是高Hcy促动脉粥样硬化重要的机制之一。
[Objective] To investigate the serum hs-CRP and homocysteine (Hcy) levels in diabetic patients. [Method] The plasma of 64 patients with no complications of diabetes, 63 patients with complications and 66 healthy subjects were collected. The concentration of hs-CRP was measured by turbidimetric immunoassay in serum latex, and the concentration of Hcy , Enzymatic determination of CHOL and TG concentrations. [Results] The serum levels of hs-CRP, Hcy, CHOL and TG in non-complication diabetic group and complication group were higher than those in normal control group (P <0.01). The serum hs-CRP and Hcy in complication group were higher than those in non-complication group (P <0.05). Correlation analysis showed that serum hs-CRP was positively correlated with CHOL and TG, while Hcy had no correlation with each index. [Conclusion] hs-CRP and Hcy have important clinical significance in the prediction of early atherosclerosis in diabetic patients. Inflammatory reaction may be one of the important mechanisms of high Hcy promoting atherosclerosis.