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用实验性胃溃疡模型研究了ＰＧ＿６Ｅ的抗溃疡作用，结果表明ＰＧ＿６Ｅ有抗胃酸分泌作用，而对胃肠运动无明显影响；ＰＧ＿６Ｅ在剂量为１０一８０μｇ·ｋｇ－１时，对无水乙醇型、盐酸型、消炎痛型、慢性醋酸型和幽门结扎型胃溃疡有明显保护作用，并能显著减少幽门结扎大鼠的胃液体积、胃酸分泌、胃蛋白酶活性和ＤＮＡ含量。小鼠ｐｏＰＧ＿６Ｅ３０～６０μｇ·ｋｇ－１，３ｄ后粘膜氨基己糖含量显著增加。研究结果提示ＰＧ＿６Ｅ能抑制对胃粘膜的攻击性因素，增加保护性因素的作用，可望成为一种新型抗胃溃疡药
The experimental gastric ulcer model was used to study the anti-ulcer effect of PG_6E. The results showed that PG_6E had anti-gastric acid secretion effect, but had no significant effect on gastrointestinal motility. When PG_6E dose was 10-80μg · kg-1, , Hydrochloric acid, indomethacin, chronic acetic acid and pylorus ligation gastric ulcer were significantly protective effect, and can significantly reduce pylorus ligation gastric volume, gastric acid secretion, pepsin activity and DNA content. Mucosal aminohexose content increased significantly after poPG_6E30 ~ 60μg · kg-1 and 3d in mice. The results suggest that PG_6E can inhibit the aggressive factors on gastric mucosa, increase the protective effect of the factor, is expected to become a new type of anti-ulcer drug