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目的：探讨ＨＢｓＡｇ阳性肝病患者合并ＨＣＶ感染后对肝脏病变的影响以及血清中ＨＣＶ存在的形式。方法：被测对象为１６８例ＨＢｓＡｇ阳性肝病患者（肝炎后肝硬化１０４例，原发性肝细胞癌６４例），采用逆转录－聚合酶链反应（ＲＴ－ＰＣＲ）检测血清中ＨＣＶＲＮＡ，采用免疫沉定法判断ＨＣＶ在血清中存在的形式。结果：ＨＢｓＡｇ阳性肝病患者合并ＨＣＶ感染者为２０．８％，与无ＨＢＶ感染人群ＨＣＶ感染率２．２％比较有显著性差异。ＨＣＶ在血清中的存在形式７７％呈游离状态，２３％既有游离状态，又有免疫复合物的形式。ＨＢｓＡｇ阳性脏病患者合并ＨＣＶ感染者肝功能损害明显加重，肝癌并发率为２６．６％。结论：ＨＢＶ与ＨＣＶ重叠感染对肝脏损伤以及并发肝癌可能有协同作用
Objective: To investigate the effect of HCV infection on liver pathology and the presence of HCV in patients with HBsAg positive liver disease. Methods: 168 patients with HBsAg positive liver disease (104 with posthepatitic cirrhosis and 64 with primary hepatocellular carcinoma) were enrolled in this study. Serum HCV RNA was detected by reverse transcription polymerase chain reaction (RT-PCR) Shen Ding law to determine the existence of HCV in the serum form. Results: The incidence of HCV infection in HBsAg-positive patients was 20.8%, which was significantly different from that in non-HBV-infected patients (2.2%). The presence of HCV in serum is 77% free, 23% free, and immune complexes. Patients with HBsAg-positive disease complicated with HCV infection significantly worse liver function, the incidence of liver cancer was 26.6%. Conclusion: Over-infection of HBV and HCV may have a synergistic effect on liver injury and liver cancer