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目的 :比较大剂量胸腺肽配合化疗与单纯化疗对乳腺癌患者的免疫功能和生活质量的改善及血液毒性的改变情况。方法 :采取随机对照分组 ,治疗组 ( 68例 )为大剂量胸腺肽联合化疗 ;对照组 ( 66例 )为单纯化疗。结果 :治疗组免疫功能测定、T细胞亚群和 NK细胞活性明显高于对照组 ,治疗组 Karnofsky评分高于对照组。结论 :大剂量胸腺肽联合化疗减少不良反应 ,提高患者的细胞免疫功能 ,改善患者生存质量。
OBJECTIVE: To compare the improvement of immune function and quality of life of patients with breast cancer treated with high-dose thymosin combined with chemotherapy and chemotherapy alone and the changes of hematological toxicity. Methods: A randomized control group was used. The treatment group (68 cases) was treated with high dose thymosin combined with chemotherapy. The control group (66 cases) was treated with chemotherapy alone. Results: The immune function, T lymphocyte subsets and NK cell activity of the treatment group were significantly higher than those of the control group. The Karnofsky score of the treatment group was higher than that of the control group. Conclusion: High-dose thymosin combined with chemotherapy can reduce adverse reactions, improve cellular immune function and improve quality of life of patients.