论文部分内容阅读
一、在林县现场以发霉的玉米面作食物,对16只Wistar大鼠进行诱癌实验。340天以前死亡的11只动物,其中8只食管无明显病变,3只有不同程度的增生性病变。喂饲445～649天自行死亡的5只大鼠,3只发生了食管癌。均为雌性大鼠。其中2例为早期浸润癌。1例为广泛浸润癌。癌均发生在食管下段。全为鳞状细胞癌。癌的发生部位和组织像与人的食管癌相似。两例未发生食管癌的大鼠,其中一例发生了食管中段的内生性上皮瘤和舌根部早期乳头瘤。另一例食管上皮发生内生性和外生性乳头状增生。从实验结果,我们认为,霉菌与人类食管癌可能有关。应开展这方面的研究。二、发霉食物与甲基苄基亚硝胺协同致癌;实验用Wistar大鼠60只。分为实验组和对照组。各组动物相同。均喂以同量的甲基苄基亚硝胺100天。实验组喂发霉食物。对照组喂未经发霉处理的食物。实验在林县现场共进行176天。结果:实验组动物的食管上皮各种类型的增生、乳头状瘤的发生率和发生的数目、癌的发生率,均高于对照组。差别显著或极显著。舌和咽部乳头状瘤和癌的发生率亦高于对照组。结果表明:在林县自然环境中发霉的食物(玉米面馍)与甲基苄基亚硝胺在大鼠的食管、舌和咽的致癌过程中,有协同作用。诱癌时间缩短,诱癌率升高。
First, on the scene in Linxian, moldy cornmeal was used as food to induce cancer in 16 Wistar rats. Of the 11 animals that died 340 days ago, 8 had no obvious lesions in the esophagus and 3 had only proliferative lesions of varying degrees. Five rats, who died on their own from 445 to 649 days, developed esophageal cancer. All female rats. Two of these cases were early invasive carcinomas. One case was extensively invasive. Cancer occurs in the lower esophagus. All squamous cell carcinoma. The location and tissue of the cancer is similar to that of human esophageal cancer. In two cases of rats without esophageal cancer, one case developed endocrine epithelial tumors in the middle esophagus and early papilloma in the base of the tongue. Another epithelium of the esophagus develops endogenous and exogenous papillary hyperplasia. From the experimental results, we believe that mold may be related to human esophageal cancer. This research should be conducted. Second, moldy food and methyl benzyl nitrosamine synergistic carcinogenic; experimental Wistar rats 60. Divided into experimental and control groups. The animals in each group are the same. All were fed with the same amount of methylbenzylnitrosamine for 100 days. The experimental group was fed moldy food. The control group was fed food that had not been mildewed. The experiment was conducted at the Linxian site for a total of 176 days. RESULTS: The incidence and incidence of various types of hyperplasia and papilloma of the esophageal epithelium in the experimental animals were higher than those in the control group. The difference is significant or extremely significant. Tongue and pharyngeal papilloma and cancer incidence was also higher than in the control group. The results showed that the moldy food (maize caruncle) and methylbenzyl nitrosamine had synergistic effects in the carcinogenesis of the esophagus, tongue and pharynx in rats in the natural environment of Linxian County. The cancer induction time is shortened and the cancer induction rate is increased.