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目的探讨血清铁蛋白的变化对拉米夫定治疗慢性乙型肝炎的影响。方法采用常规方法观察34例拉米夫定治疗乙型肝炎患者临床疗效与血清铁蛋白水平的关系。结果血清铁蛋白的增高与肝脏病变的严重程度呈正比。在拉米夫定治疗的34例患者中,血清铁蛋白水平<300ng/ml者疗效明显优于300ng/ml以上者(P<0.005),提示血清铁蛋白水平增高使患者对拉米夫定的反应降低,在有治疗反应的22例患者中,持续反应者与暂时反应者血清铁蛋白均值差异有统计学意义(t=4.147,P<0.005)。结论血清铁蛋白水平较高可能降低对拉米夫定治疗的反应性且使疗效不持久。
Objective To investigate the effect of serum ferritin on lamivudine treatment of chronic hepatitis B Methods The routine method was used to observe the relationship between clinical efficacy and serum ferritin in 34 patients with hepatitis B treated by lamivudine. Results Serum ferritin increased in proportion to the severity of liver disease. Among the 34 patients treated with lamivudine, the serum ferritin level of <300 ng / ml was significantly better than that of 300 ng / ml (P <0.005), suggesting that elevated serum ferritin levels may lead patients to lamivudine The response was decreased. Among the 22 patients who responded to the therapy, there was a significant difference in the mean serum ferritin between the responders and the transient responders (t = 4.147, P <0.005). Conclusions A higher serum ferritin level may reduce the response to lamivudine treatment and will not lead to long-term curative effect.