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目的:观察辛伐他汀治疗女性糖尿病伴高脂血症及骨质疏松患者的临床疗效。方法:将温州医学院附属第一医院2007年6月～2009年12月收治的糖尿病伴高脂血症及骨质疏松的患者60例随机分为治疗组和对照组,两组均在常规治疗糖尿病的基础上,对照组采用口服非诺贝特0.2,治疗组采用口服辛伐他汀20mg治疗,每晚顿服。均以12个月为一个疗程,比较两组患者的骨钙素(BGP)、L2～4及股骨颈的骨密度(BMD),血清钙(Ca)、磷(P)及碱性磷酸酶(ALP)。结果:两组患者治疗前后血清Ca、P水平无显著变化(P>0.05)。治疗组的BGP、L2～4及股骨颈的BMD、ALP的改善程度显著高于对照组(P<0.05)。结论:辛伐他汀能促进骨细胞增殖,抗骨吸收,促进成骨细胞产生骨钙素,长期治疗能够改善骨密度,促进BGP升高,并且通过促进血管形成、抑制炎症作用而缓解病情。
Objective: To observe the clinical effect of simvastatin on female patients with diabetes mellitus and hyperlipidemia and osteoporosis. Methods: Sixty patients with diabetes mellitus and hyperlipidemia and osteoporosis who were admitted to the First Affiliated Hospital of Wenzhou Medical College from June 2007 to December 2009 were randomly divided into treatment group and control group. Both groups were treated with routine treatment On the basis of diabetes, the control group with oral fenofibrate 0.2, the treatment group with oral simvastatin 20mg treatment, Dayton clothing. (12 months) were used as a course of treatment to compare the bone mineral density (BGP), L2 ~ 4 and femoral neck BMD, serum Ca, P and ALP ALP). Results: Before and after treatment, serum Ca and P levels did not change significantly (P> 0.05). The improvement of BGP, L2 ~ 4 and femoral neck BMD and ALP in the treatment group was significantly higher than that in the control group (P <0.05). Conclusion: Simvastatin can promote bone cell proliferation, anti-bone resorption and promote osteoblast to produce osteocalcin. Long-term treatment can improve bone density, promote BGP elevation, and alleviate the disease by promoting angiogenesis and inhibiting inflammation.