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分析了难治性肾病综合征五年肾稳定的主要因素。将60例难治性肾病综合征分为激素与综合治疗两组,五年内动态观察21项指标,对各参数用COX模型进行单因素与多因素分析。结果:血尿皮质醇及GC的应用是五年肾稳定的主要危险因子。结论:五年肾稳定率激素组为15.4%,综合组为76%,体内外GC可能是难治性肾病综合征进展的重要因素。
The main factors of five-year renal stability in refractory nephrotic syndrome were analyzed. Sixty patients with refractory nephrotic syndrome were divided into two groups according to hormones and comprehensive treatment. 21 indicators were observed dynamically in five years, and all parameters were analyzed by univariate and multivariate analysis using COX model. Results: The application of hematuria and cortisol and GC was the main risk factor of five-year renal stability. CONCLUSION: The five-year renal stability rate was 15.4% in the hormone group and 76% in the combined group. GC in vitro and in vivo may be an important factor in the progression of refractory nephrotic syndrome.