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外周血管狭窄引起血管阻力增加是介导高血压病理生理学改变的一个主要血流动力学因素。阻力与半径的 4次方成反比 ,因此血管内径的轻微改变就可以显著影响血管阻力。高血压时由于功能、结构和机械性改变 ,血管内径缩小 ,外周阻力增加。功能性改变包括应力增加或舒张力功能受损
Increased vascular resistance caused by peripheral vascular stenosis is a major hemodynamic factor that mediates the pathophysiology of hypertension. Resistance is inversely proportional to the fourth power of the radius, so a slight change in vascular diameter can significantly affect vascular resistance. Hypertension due to functional, structural and mechanical changes, vascular diameter narrowing, peripheral resistance increased. Functional changes include increased stress or impaired diastolic function