Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-

• 作 者: 宋新建 王旭梅 孙琦 黄生田 王艳
• 机 构: CollegeofChemistryandEnvironmentalEngineering,SchoolofChemicalandEnvironmentalEngineering
• 出 处: 结构化学
• 发表日期: 2019年7期
• 关键词: 1 3 4-THIADIAZOLE UREA crystal structure ANTITUMOR activity
• 基金项目: the National Natural Science Foundation ofChina (No. 21262012),the Natural Science Foundation of Hubei Province (No. 2016CFB400).

N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a~4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single crystal of compound 4 a, C17 H13 FN4 OS