【摘 要】
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Coronaviruses are large, enveloped, positive-strand RNA viruses.Several coronaviruses are pathogenic in humans,including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and this novel virus
【机 构】
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Department of Infectious Diseases, The Second Hospital of Nanjing, The Affiliated Hospital of Nanjin
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Coronaviruses are large, enveloped, positive-strand RNA viruses.Several coronaviruses are pathogenic in humans,including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and this novel virus, SARS-CoV-2,which has caused the global pandemic currently.Genetic sequencing suggests that SARS-CoV-2 is related to SARS-CoV and its close relatives (Chen et al.2020).There are four genera of coronavirus, including Alphacoronavirus,Betacoronavirus, Gammacoronavirus and Deltacoronavirus.Like other Betacoronaviruses, the genome of SARS-CoV-2 codes four major structural proteins,including the spike surface glycoprotein which is called S protein, small envelope protein, matrix protein, and nucleocapsid protein.S proteins are type Ⅰ transmembrane proteins with a large ectodomain and a short endodomain.
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