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目的对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)所致不孕症患者采用腹腔镜下卵巢表面电凝术治疗的临床效果进行分析,并对其安全性进行探讨。方法选取河南省安阳市人民医院妇产科2012年1月至2013年5月收治的60例PCOS患者,随机分为观察组和对照组,每组各30例。观察组采用腹腔镜下卵巢表面电凝术治疗,对照组采用口服二甲双胍治疗。观察两组患者治疗前后的血黄体生成素(luteinizing hormone,LH)、卵泡刺激素(follicle-stimulating hormone,FSH)、睾酮(testosterone,T)以及空腹血胰岛素(Insulin,INS)水平,并对两组患者治疗后出现的不良反应进行分析。结果观察组治疗后的胰岛素抵抗(insulin resistance,IR)、LH、FSH、T以及INS改善情况优于对照组(P<0.05);术后24周内妊娠率高于对照组(60.0%vs 36.7%,P<0.05);不良反应低于对照组(0%vs 16.67%,P<0.05)。结论对PCOS患者采用腹腔镜下卵巢表面电凝术治疗,能够有效的改善患者的临床症状并提高其妊娠率,是有效的治疗手段。
Objective To analyze the clinical effect of laparoscopic ovarian surface electrocoagulation (ESP) in patients with infertility caused by polycystic ovarian syndrome (PCOS) and to investigate its safety. Methods Sixty patients with PCOS who were admitted to Obstetrics and Gynecology Hospital of Anyang People’s Hospital of Henan Province from January 2012 to May 2013 were randomly divided into observation group and control group with 30 cases in each group. The observation group was treated with laparoscopic ovarian surface electrocoagulation and the control group with oral metformin treatment. The levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) and insulin (INS) were measured before and after treatment in both groups. Group of patients after treatment of adverse reactions were analyzed. Results The improvement of insulin resistance (IR), LH, FSH, T and INS in the observation group was better than that in the control group (P <0.05). The pregnancy rate in the 24 weeks after operation was higher than that in the control group (60.0% vs 36.7 %, P <0.05). Adverse reactions were lower than those in the control group (0% vs 16.67%, P <0.05). Conclusion The treatment of PCOS patients with laparoscopic ovarian surface electrocoagulation, which can effectively improve the clinical symptoms and improve the pregnancy rate, is an effective treatment.