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本研究对尿毒症血透析过程中血浆ｔ－ＰＡ、ＰＡＩ进行动态观察。结果表明：血液透析中ｔ－ＰＡ活性明显降低，而ＰＡＩ明显升高，至透析结束最明显。透析前ｔ－ＰＡ与ＰＡＩ活性分别与透析２小时、透析结束比较，以及透析２小时与透析结束比较，均有显著性差异（Ｐ＜０．０５）或非常显著性差异（Ｐ＜０．０１）。提示：血液透析使尿毒症思者纤溶系统受损，易于形成血栓。
This study of uremic hemodialysis during plasma t-PA, PAI dynamic observation. The results showed that t-PA activity in hemodialysis was significantly decreased, while PAI was significantly increased to the end of dialysis the most obvious. Pretreatment t-PA and PAI activity were significantly different (P <0.05) or very significant difference (P <0.01) compared with dialysis 2 hours, dialysis end, dialysis 2 hours and dialysis end ). Hint: hemodialysis makes urethritis think fibrinolytic system damage, easy to form thrombus.