论文部分内容阅读
目的分析2例首发于肺部的 NK/T 细胞淋巴瘤的临床、影像学及病理特征。方法回顾性分析南京大学医学院附属鼓楼医院呼吸科收治的2例以肺部为首发部位的 NK/T 细胞淋巴瘤患者的临床、影像学及病理资料,并复习相关文献。结果 2例均为年轻女性患者,首发病灶部位均为肺部,通过 CT 引导下经皮肺穿刺活检病理证实为 NK/T 细胞淋巴瘤。2例患者有类似的临床表现,包括发热、干咳、呼吸困难,呈进行性进展并发呼吸衰竭。2例患者胸部 CT 表现为双肺多发实变影,部分病灶显示有空气支气管征和晕环征,伴有胸腔积液。2例患者的血浆 EB 病毒 DNA 检测结果分别为3.65×10~5拷贝/ml、1000拷贝/ml。由于病情进展迅速,2例患者的生存期仅分别为44d 和66d。结论肺部可以是 NK/T 细胞淋巴瘤首发侵袭部位,预后凶险。
Objective To analyze the clinical, radiological and pathological features of 2 cases of NK / T cell lymphoma in the lungs. Methods The clinical, imaging and pathological data of 2 cases of NK / T cell lymphoma with lung as the primary site admitted to Respiratory Department of Drum Tower Hospital affiliated to Nanjing University Medical College were reviewed retrospectively. The related literatures were reviewed. Results Both of the two cases were young female patients. The first lesion was all lung. The pathological examination of percutaneous lung biopsy under CT guidance was NK / T cell lymphoma. Two patients had similar clinical manifestations including fever, dry cough, dyspnea, progressive progression complicated with respiratory failure. Two cases of chest CT manifestations of multiple lung consolidation strabismus, some lesions showed signs of air bronchogram and halo, associated with pleural effusion. Plasma Epstein-Barr virus DNA test results of 2 patients were 3.65 × 10 ~ 5 copies / ml and 1000 copies / ml, respectively. As the disease progressed rapidly, the survival of 2 patients was only 44d and 66d respectively. Conclusion The lungs may be the first invasion sites of NK / T cell lymphoma, with a dangerous prognosis.