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利用ＨＩＶ受体ＣＤ４分子Ｖ１Ｖ２区的基因取代绿脓毒素（ＰＥ）中与细胞结合的功能区ｄｏｍａｉｎⅠ的基因，构建ＣＤ４Ｖ１Ｖ２－ＰＥ４０融合基因并在大肠杆菌中表达出ＣＤ４Ｖ１Ｖ２－ＰＥ４０融合蛋白。该融合蛋白可杀灭被ＨＩＶ感染的细胞，中和游离的ＨＩＶ，有希望成为治疗艾滋病的一种新药。
The CD4V1V2-PE40 fusion gene was constructed and the CD4V1V2-PE40 fusion protein was expressed in Escherichia coli by using the gene of domain V1 of cell region associated with the cytokines in the green porphyrin (PE) by replacing the V1V2 region of HIV receptor CD4 molecule. The fusion protein can kill HIV-infected cells and neutralize free HIV, promising to be a new drug for the treatment of AIDS.