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目的 :为探讨胃癌组织中 p5 3蛋白表达和 PCNA评分之间的相关性。方法 :运用免疫组织化学L SAB方法 ,对 6 8例原发性胃癌组织进行标记。结果 :p5 3蛋白表达阳性率 45 .5 8% (31/6 8) ,PCNA评分值 2 .40 0±1.10 1。 p5 3阳性和 PCNA评分在组织学分级 级、无淋巴结转移者明显低于组织学分级 级、有淋巴结转移者 ,分别为 (P<0 .0 5、P<0 .0 1)。结论 :p5 3蛋白和 PCNA与胃癌的发生、发展密切相关 ,可能是反映胃癌生物学行为和预测预后的重要标记物。
Objective : To investigate the correlation between p53 protein expression and PCNA score in gastric cancer. Methods: Sixty-eight primary gastric cancer tissues were labeled by immunohistochemical L SAB method. Results: The positive rate of p53 protein expression was 45.5% (31/68), and the PCNA score was 2.40 0±1.10 1. The p53 positive and PCNA scores were significantly lower in histological grade and no lymph node metastasis than in histological grade and lymph node metastasis (P < 0.05, P <0.01). Conclusion : p53 protein and PCNA are closely related to the occurrence and development of gastric cancer, and may be important markers reflecting the biological behavior and predicting prognosis of gastric cancer.