Comparative study of effects of bone marrow cell vs. Ad5-HGF administration via non-infarct-related

• 作 者: Liansheng Wang Zhijian Yang We
• 机 构: DepartmentofCardiology,DepartmentofCardiology
• 出 处: 南京医科大学学报：英文版
• 发表日期: 2007年2期
• 关键词: 骨髓细胞 动脉 心肌梗塞 猪 动物实验 Bone marrow-derived mesenchymal stem cells hepatocyte growt
• 基金项目: This work was supported by a grant from Science Committee of Jiangsu Province（NoRC2002043）. The assistance of Dr. Zhaoqiang Xu was gratefully acknowledged. We also thank Prof. Paul J. Boor, University

评估移植骨头的效果的目的导出髓的间充质的干细胞(BM-MSCs ) 或经由在心肌的梗塞建模的猪的 non-infarct-related 动脉注射的 adenovirus5-hepatocyte 生长因素(Ad5-HGF ) 。方法 BM-MSCs 从猪骨头髓被获得并且在 vitro 膨胀了到纯净 >50% 。心肌的梗塞(MI ) 被绑扎创造在猪的远侧的左前面的下降动脉。BM-MSCs (5 脳 106/ml ) 或 Ad5-HGF (4 脳 109 pfu ) 四个星期在 MI 以后经由恰好冠的动