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目的探讨胃癌患病风险的炎性基因白介素1(IL-1)、肿瘤坏死因子(TNF)及巨噬细胞转移抑制因子(MIF)与环境间交互作用。方法用多因子降维法(MDR)模型分析基因-环境的交互作用对胃癌易感性影响,结合logistic回归分析进行补充验证。结果最佳交互作用模型是IL-1B-511、IL-1RN、TNF-A-308和肿瘤家族史的联合作用(P<0.01),交叉验证一致性10/10,检验样本准确度为0.72;根据模型将研究对象划分为高危、低危人群,胃癌发病风险交互效应的危险度估计OR=13.49,95%CI=8.62～21.10,且交互作用有统计学意义(P<0.01);将危险因素按结合数量进行分析,结果显示含有1、2、3个危险因素组在病例和对照中分布差异均有统计学意义(P<0.05),OR值分别为2.17、11.61、27.19。结论 IL-1B-511、IL-1RN、TNF-A-308和肿瘤家族史的交互作用可能增加胃癌患病风险。
Objective To investigate the interaction between interleukin 1 (IL-1), tumor necrosis factor (TNF) and macrophage migration inhibitory factor (MIF) in the human gastric cancer and its environment. Methods The multifactorial dimensionality reduction (MDR) model was used to analyze the effect of gene-environment interaction on the susceptibility to gastric cancer, and the results were validated by logistic regression analysis. Results The best interaction model was the combined effect of IL-1B-511, IL-1RN, TNF-A-308 and tumor family history (P <0.01), cross-validation consistency 10/10 and test sample accuracy 0.72; According to the model, subjects were divided into high-risk and low-risk groups. The risk of gastric cancer risk interaction estimated OR = 13.49,95% CI = 8.62 ~ 21.10, and the interaction was statistically significant (P <0.01) According to the number of combined analysis, the results showed that there were significant differences in the distribution of 1, 2 and 3 risk factors between cases and controls (P <0.05), with OR values of 2.17, 11.61 and 27.19 respectively. Conclusion The interaction of IL-1B-511, IL-1RN, TNF-A-308 and tumor family history may increase the risk of gastric cancer.