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特发性微小变化肾病(MCN)和局灶性节段性肾小球硬化(FSGS)被认为与T淋巴细胞功能异常有关,细胞激动素的生成紊乱导致肾小球对液体和大分子的通透性增加。作者观察第一例MCN伴轻度肾小球膜增生的肾病综合征,长期的类固醇加硫唑嘌呤以及环孢菌素治疗均未能使蛋白尿缓解,且诱发了严重的感染并发症。用培氟沙星(pefloxacin)治疗15天后完全缓解。
Idiopathic small changes in nephropathy (MCN) and focal segmental glomerulosclerosis (FSGS) are thought to be associated with dysfunction of T lymphocytes, disorders of the production of cytokinin leading to the passage of glomeruli to liquids and macromolecules Permeability increases. The authors observed the first case of nephrotic syndrome with mild mesangium hyperplasia in MCN. Long-term steroid plus azathioprine and cyclosporin treatment failed to relieve proteinuria and caused severe complications of infection. Complete remission after 15 days treatment with pefloxacin.