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目的探讨黄体期使用生长激素(GH)对高龄卵巢储备功能减退(DOR)患者超促排卵治疗的影响。方法选择接受体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)且高龄(年龄≥35岁)DOR不孕患者156例为研究对象,均采用拮抗剂方案,分为研究组(加用GH)和对照组(不加用GH)。分析GH对促性腺激素(G n)使用总量、G n使用时间、获卵数、移植前内膜厚度、双原核(2 P N)率、优质胚胎率、着床率的影响。结果 Gn使用时间、Gn使用总量、移植前内膜厚度组间有统计学差异(P<0.05)。h CG注射日E 2水平、获卵数、2 P N受精率、优质胚胎率、着床率、临床妊娠率及累积妊娠率组间无统计学差异(P>0.05)。研究组临床妊娠率为28.0%、对照组为19.4%,研究组累积妊娠率为33.3%、对照组为20.0%,组间均无统计学差异(P>0.05),但研究组临床妊娠率及累积妊娠率有上升趋势。结论 GH对年龄≥35岁DOR患者可明显降低Gn的使用总量及使用时间,增加子宫内膜的厚度,临床妊娠率及累积妊娠率有提高的趋势。
Objective To investigate the effect of luteal phase using growth hormone (GH) on ovarian hyperstimulation in elderly patients with ovarian reserve loss (DOR). Methods A total of 156 elderly patients (≥35 years old) with DOR infertility who underwent in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) were enrolled in this study. All the patients were divided into Study group (plus GH) and control group (without GH). The effects of GH on total Gn use, G n usage time, number of oocytes retrieved, thickness of intima before transplantation, 2 P N rate, high quality embryo rate and implantation rate were analyzed. Results The time of Gn use, the total amount of Gn usage, and the thickness of the intima before transplantation were significantly different (P <0.05). There was no significant difference between E 2 level, number of oocytes retrieved, fertilization rate of 2 P N, rate of high quality embryo, implantation rate, clinical pregnancy rate and cumulative pregnancy rate on CG injection day (P> 0.05). The clinical pregnancy rate was 28.0% in the study group and 19.4% in the control group. The cumulative pregnancy rate was 33.3% in the study group and 20.0% in the control group. There was no significant difference between the two groups (P> 0.05) The cumulative pregnancy rate is on the rise. Conclusion GH in patients with DOR ≥35 years old can significantly reduce the total amount of Gn and the use of time, increasing the thickness of the endometrium, clinical pregnancy rate and cumulative pregnancy rate has increased.