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目的探讨近1年来我院对胎儿唐氏综合征的产前检查工作成效。方法以2010年5月至2011年5月前来我院产科就诊的妊娠时间为14～20+6孕周的自愿接受胎儿唐氏综合征产前筛查的孕妇共500例为研究对象。对其进行血清甲胎蛋白联合游离β-人绒毛膜促性腺激素的检测,筛查胎儿唐氏综合征的患病率并予以遗传咨询,降低畸形儿的出生率。结果 107例孕妇产前唐氏筛查风险率较高,为6.20%,其中,唐氏综合征的阳性孕妇为30例。而自愿接受羊水穿刺检测胎儿染色体的100例唐氏综合征高风险妊娠中期的孕妇中发现胎儿染色体异常者有5例,异常检测率为3.81%,其中唐氏综合征1例,18-三体综合症1例,其它3例。结论在孕妇怀孕中期进行唐氏综合征筛查能有效预测胎儿异常以及不良妊娠的方法和措施。
Objective To investigate the effectiveness of prenatal examination of fetal Down Syndrome in our hospital in the past year. Methods From May 2010 to May 2011, 500 pregnant women, who volunteered for prenatal screening of fetal Down Syndrome, were enrolled in our hospital from 14 to 20 + 6 gestational weeks. Serum a-fetoprotein combined with free β-human chorionic gonadotropin testing, screening of fetal Down Syndrome prevalence and genetic counseling to reduce the birth rate of deformed children. Results The prenatal screening of 107 pregnant women had a higher risk of prenatal screening, which was 6.20%. Among them, 30 were positive pregnant women with Down’s Syndrome. Five of the 100 fetuses with fetal chromosomal abnormalities were found in 100 pregnant women with high risk of Down’s syndrome who received amniocentesis for detection of fetal chromosomes. The detection rate was 3.81%, of which 1 was Down Syndrome, 18- Syndrome in 1 case, the other 3 cases. Conclusion Down’s syndrome screening during the second trimester of pregnant women can effectively predict fetal abnormalities and adverse pregnancy methods and measures.