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IgG Fc受体(FcγR)是免疫应答中重要的膜性调节分子,表达于几乎所有白细胞的表面,是连接体液免疫和细胞免疫的桥梁。FcγR不仅介导免疫细胞的活化和效应的发挥,而且在特定条件下参与免疫损伤,构成某些免疫相关性疾病的病理机制。近年来,FcγR及其基因多态性在自身免疫性疾病发生发展中的作用及免疫靶向干预引起了国内外学者的关注。
The IgG Fc receptor (FcγR), an important membrane-modulating molecule in immune response, is expressed on the surface of almost all leukocytes and serves as a bridge between humoral and cellular immunity. FcγR not only mediates the activation of immune cells and the effect of play, but also under certain conditions involved in immune damage, constitute the pathological mechanism of some immune-related diseases. In recent years, the role of FcγR and its genetic polymorphisms in the development of autoimmune diseases and immunological targeting have attracted the attention of scholars at home and abroad.