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动脉粥样硬化是心脏移植病人长期生存的主要障碍,移植后血浆甘油三酯和脂蛋白胆固醇浓度升高可能导致移植心脏粥样硬化。作者比较72例心脏移植病人与51例健康对照者,研究免疫抑制剂对血浆甘油三酯、低密度脂蛋白(LDL)胆固醇、高密度脂蛋白(HDL)胆固醇、HDL亚成分(HDL_2和HDL_3)胆固醇、肝脂酶和脂蛋白脂酶的影响。发现移植组血浆甘油三酯浓度升高80％(P<0.001),LDL胆固醇升高16％(P<0.005),
Atherosclerosis is a major obstacle to the long-term survival of patients undergoing heart transplantation. Elevated plasma triglycerides and lipoprotein cholesterol levels after transplantation may lead to atherogenic heart grafts. The authors compared the effects of immunosuppressive agents on plasma triglycerides, LDL cholesterol, HDL cholesterol, HDL subtypes (HDL_2 and HDL_3) in 72 heart transplant patients and 51 healthy controls. Effects of cholesterol, hepatic lipase and lipoprotein lipase. It was found that plasma triglyceride concentrations increased by 80% (P <0.001) and LDL cholesterol by 16% (P <0.005) in the transplant group,