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采用放射免疫分析法对无合并肾炎和肾病的50例甲亢患者,进行血清和尿液中的β_2—M 测定。发现甲亢患者血清β_2—M 平均浓度为3.701mg/L,94%的甲亢患者血清β_2—M 高于正常人(P<0.01)。甲亢患者尿液中β_2—M 平均浓度为0.163mg/L,50%的甲亢患者尿液中β_2—M 浓度高于正常人(P<0.01)。甲亢患者血清和尿液中β_2—M 值之间无相关性。从而提示了甲亢患者多数伴有肾脏机能损伤。
Fifty patients with hyperthyroidism without nephritis and nephropathy were subjected to radioimmunoassay to determine β_2-M in serum and urine. The mean β_2-M concentration in patients with hyperthyroidism was 3.701mg / L, and the serum β_2-M level was higher in 94% of hyperthyroid patients than in normal people (P <0.01). The average concentration of β_2-M in urine of patients with hyperthyroidism was 0.163mg / L, and the concentration of β_2-M in urine of 50% patients with hyperthyroidism was higher than that of normal people (P <0.01). There was no correlation between β_2-M in serum and urine of patients with hyperthyroidism. Thus prompted the majority of patients with hyperthyroidism with renal impairment.