Separation and Determination of Methylnaltrexone in Human Plasma Samples After Oral Administration b

• 作 者: WANGAn-bao JosephF.Foss YUANCh
• 机 构: DepartmentofAnesthesiaandCriticalCare,DepartmentofAnesthesiaandCriticalCare
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2005年3期
• 关键词: 甲基环丙甲羟二羟吗啡酮 人体 血浆 高性能液体色谱 电化学探测技术 药物 止咳药 Liquid chromatography Electrochemical
• 基金项目: the Institutional American Cancer Society，the International Anesthesia Research Society and Clinical Practice Enhancement and Anesthesia Research Foundation

A high performance liquid chromatography(HPLC) method coupled with electrochemical detection and solid phase extraction is described for the separation and determination of methylnaltrexone(MNTX), a quaternary opioid antagonist, in human clinical plasma s