2型糖尿病患者糖化血红蛋白和心血管转归:1项巢式病例对照研究

• 作 者: 本刊编辑部
• 出 处: 中国糖尿病杂志
• 发表日期: 2011年02期
• 关键词: 心血管事件 血红蛋白 转归 糖尿病 非致死性 保健机构 逻辑回归 模型评估 心血管疾病 Kaiser

2型糖尿病(T2DM)与心血管疾病风险增加相关,而强化血糖控制对于防止心血管事件的作用却尚未明确。1项巢式病例对照研究用以评价平均糖化血红蛋白(HbA_1 c)与心血管转归之间的关系。该项巢式病例对照研究共纳入美国南加利福尼亚凯撒保健机构(Kaiser Permanente Southern California)的11 157例患者,并选择44 628名年龄、性别等均匹配的对照者(每4例患者对应1名对照者)。按照平均HbA_1 c≤6%、>6%～8%和>8%分为3组,用逻辑回归模型评估和比较3组患者随访3年期间的心血管事件:非致死性心肌梗死和卒中或死于心血管事件。

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular disease, but the role of intensive glycemic control in preventing cardiovascular events is unclear. A nested case-control study evaluated the relationship between mean HbA 1c and cardiovascular outcomes. The nested case-control study included 11 157 patients enrolled in Kaiser Permanente Southern California, USA, and selected 44 628 matched controls of age and gender (one for each 4 patients By). The patients were divided into three groups according to the mean HbA_1 c≤6%,> 6% -8% and> 8%. Logistic regression models were used to evaluate and compare the cardiovascular events of three groups at follow-up of 3 years: non-fatal myocardial infarction and stroke Died of a cardiovascular event.