论文部分内容阅读
目的:探讨氟康唑滴眼液中抑菌剂的合理添加剂量。方法:按照中国药典2015年版抑菌剂效力检查法,以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉为试验菌株,对分别含4个不同浓度抑菌剂(5%,1%,0.3%,0.1%苯扎氯铵)的氟康唑滴眼液进行抑菌剂效力测定。结果:含5%,1%,0.3%苯扎氯铵的氟康唑滴眼液对金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉5种试验菌的抑菌效力均符合规定,0.1%苯扎氯铵对铜绿假单胞菌抑菌效力不符合规定,0.3%为苯扎氯铵的最低抑菌浓度。结论:确定苯扎氯铵的最佳抑菌浓度为1%。
Objective: To investigate the reasonable dosages of bacteriostats in fluconazole eye drops. Methods: According to the Chinese Pharmacopoeia 2015 edition of the bacteriostatic efficacy test, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergillus niger as test strains, respectively, containing 4 different concentrations of antibacterial (5%, 1%, 0.3%, 0.1% benzalkonium chloride) fluconazole eye drops were tested for their bacteriostatic efficacy. Results: Fluconazole eye drops containing 5%, 1% and 0.3% benzalkonium chloride had no effect on five kinds of test bacteria, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergillus niger Antibacterial efficacy are in line with the provisions of 0.1% benzalkonium chloride on the bacteriostatic efficacy of Pseudomonas aeruginosa does not meet the requirements, 0.3% benzalkonium chloride minimum inhibitory concentration. Conclusion: The best antibacterial concentration of benzalkonium chloride is 1%.