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某些抗肿瘤剂如TNF-α和喜树碱(CPT)因能激活NF-κB途径,导致抗凋亡蛋白增加而常引起肿瘤细胞对抗癌药物的耐药性。因此,NF-κB途径抑制剂与抗肿瘤药物合用是肿瘤化疗的有益尝试。作者研究了叶苔属植物Jungermannia truncata Nees中贝壳杉烯二萜类化合物ent-11α-羟基-16-贝壳杉烯-15-酮(KD)是否具有NF-κB抑制活性和增强TNF-α或CPT诱导肿瘤细胞凋亡的作用。
Certain anti-neoplastic agents such as TNF-α and camptothecin (CPT) can activate the NF-κB pathway, leading to an increase in anti-apoptotic proteins and often cause tumor cells to become resistant to anti-cancer drugs. Therefore, the combination of NF-κB pathway inhibitors and anti-tumor drugs is a beneficial attempt for cancer chemotherapy. The authors investigated whether the katoterine diterpenoid ent-11α-hydroxy-16-kauren-15-one (KD) in the genus Jungermannia truncata Nees has NF-κB inhibitory activity and potentiates TNF-α or CPT. Induces apoptosis of tumor cells.