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目的:探讨左氧氟沙星治疗耐多药肺结核病(MDR-TB)效果。方法:MDR-TB患者120例随机分为为观察组及对照组各60例,对照组应用3 HZHhT/12 HZHhT,观察组在对照组的基础上加V(3 HZHhTV/12 HZHhTV),疗程15个月。结果:观察组痰结核菌涂片阴转、病灶改善情况、疗效好于对照组(P<0.05)。观察组不良反应发生31.6%,与对照组(28.3%)比较无统计学差异(P>0.05)。结论:应用左氧氟沙星联合其他治疗药物治疗MDR-TB,有助于痰菌阴转和病变的吸收,疗效确切,药物不良反应低。
Objective: To investigate the efficacy of levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods: 120 patients with MDR-TB were randomly divided into observation group and control group, 60 cases in each group. The control group was given 3 HZHhT / 12 HZHhT. The observation group was treated with V (3 HZHhTV / 12 HZHhTV) Months. Results: The observation group sputum TB smear negative conversion, lesion improvement, the effect is better than the control group (P <0.05). Adverse reactions in the observation group occurred in 31.6%, which showed no significant difference compared with the control group (28.3%) (P> 0.05). Conclusion: The combination of levofloxacin and other drugs in the treatment of MDR-TB can help to improve the absorption of sputum negative conversion and pathological changes. The curative effect is definite and the adverse drug reaction is low.