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目的探讨吲达帕胺治疗老年单纯收缩期高血压的有效性和安全性。方法选择老年单纯收缩期高血压患者168例,随机分为治疗组(n=98)和对照组(n=70)。治疗组予吲达帕胺治疗,对照组口服苯磺酸左旋氨氯地平片。两组用法都为2.5mg/次,1次/d,效果不佳者4周后增至5mg/d,顿服。两组各治疗12周,对其临床疗效进行观察比较。结果两组治疗后收缩压及舒张压均较治疗前明显下降(P<0.01),且用药12周后治疗组和对照组相比,收缩压下降明显(P<0.005),但舒张压下降幅度较小,两组间的差异有统计学意义(P<0.05)。结论吲达帕胺治疗老年单纯收缩期高血压,不仅可控制收缩压,且对舒张压影响较小,从而缩小脉压,进一步减少并发症发生。
Objective To investigate the efficacy and safety of indapamide in the treatment of elderly isolated systolic hypertension. Methods A total of 168 elderly patients with isolated systolic hypertension were randomly divided into treatment group (n = 98) and control group (n = 70). The treatment group was treated with indapamide, the control group oral levamlodipine besylate tablets. Two groups of usage are 2.5mg / time, 1 time / d, poor performance after 4 weeks to 5mg / d, Dayton clothing. The two groups were treated for 12 weeks, their clinical efficacy were observed and compared. Results After treatment, the systolic and diastolic blood pressure were significantly decreased in both groups (P <0.01). Compared with the control group, the systolic blood pressure decreased significantly (P <0.005) after 12 weeks of treatment, but the decrease of diastolic blood pressure The differences between the two groups were statistically significant (P <0.05). Conclusion Indapamide treatment of isolated systolic hypertension in elderly patients can not only control the systolic pressure but also have little effect on the diastolic pressure, thus reducing the pulse pressure and further reducing the incidence of complications.