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目的考察盐酸昂丹司琼注射液和注射用地塞米松磷酸钠的配伍相容性。方法模拟临床输液实际情况,在室温(25℃)不避光环境下,将临床常用量盐酸昂丹司琼在5%葡萄糖注射液或0.9%氯化钠注射液输液袋中与注射用地塞米松磷酸钠混合配伍,分别在0(配置后即刻)、3、6、24 h观察外观,测定不溶性微粒、p H值、盐酸昂丹司琼和地塞米松磷酸钠的药物浓度。结果上述配伍输液在24 h内均无浑浊、无变色、无沉淀和气体产生等,不溶性微粒符合规定标准,p H值和两种药物浓度保持恒定。结论临床常用量盐酸昂丹司琼注射液可以与注射用地塞米松磷酸钠在常用输液中配伍使用。
Objective To investigate the compatible compatibility between ondansetron hydrochloride injection and dexamethasone sodium phosphate injection. Methods The actual situation of clinical infusion was simulated. In the environment of room temperature (25 ℃) without light, the common clinical dose of ondansetron hydrochloride in 5% dextrose injection or 0.9% sodium chloride injection infusion bag was compared with dexamethasone for injection Sodium phosphate was mixed and mixed at 0 (immediately after configuration), and the appearance was observed at 3, 6 and 24 h. The drug concentration of insoluble particles, p H value, ondansetron hydrochloride and dexamethasone sodium phosphate were determined. Results The above compatibility infusion had no turbidity, no discoloration, no precipitation and gas generation within 24 h. The insoluble particles were in compliance with the prescribed standard, and the p H value and the two drug concentrations were kept constant. Conclusion The commonly used clinical dose of ondansetron hydrochloride injection can be used in combination with dexamethasone sodium phosphate injection in the common infusion.