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[目的]评价上海市徐汇区2名健康儿童检出脊髓灰质炎疫苗衍生病毒(VDPV)的调查处置措施。[方法]分别对2名病毒携带者进行个案调查、粪便消毒处置、测定免疫功能,采集粪便标本分离病毒。对密切接触者和周围健康儿童粪便标本进行带毒调查、儿童脊髓灰质炎减毒活疫苗(OPV)接种率调查、OPV查漏补种及医疗机构急性弛缓性麻痹(AFP)病例主动搜索。[结果]2名健康儿童分别检出Ⅲ型VDPV和脊灰疫苗高变异株病毒。当地儿童OPV免疫接种率较高,粪便标本均未检出阳性病毒。未发现VDPV病例。[结论]VDPV未在当地造成循环。
[Objective] To evaluate the investigation and treatment of poliovirus vaccine-derived virus (VDPV) in 2 healthy children in Xuhui District of Shanghai. [Method] Two cases of virus carriers were investigated individually, the feces was disinfected, the immune function was measured, and the stool samples were collected to separate the virus. Infected investigations of stool specimens from close contacts and surrounding healthy children, inoculation of live attenuated poliovirus (OPV) in children, OPV leak detection and replantation, and active flaccid paralysis (AFP) in medical institutions were actively searched. [Results] Two healthy children were detected type VDPV and poliovirus high variant virus. Local children had a higher rate of OPV immunization, and no positive virus was detected in stool specimens. VDPV cases were not found. [Conclusion] VDPV did not cause circulation in the local area.