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目的:研究肠癌患者中与铁代谢相关的铁调素(Hepcidin)、神经元特异性烯醇化酶(Neogenin,NEO)的表达特点及其与临床特征、贫血的关系。方法:应用免疫组化方法检测62例肠癌患者肿瘤组织中Hepcidin及NEO的表达情况,并分析它们之间的相互关系及其与临床特征、贫血的关系。结果:铁调素的表达与患者T分期有关(P<0.05),而与淋巴结转移、远处转移均无关。NEO的表达与患者T分期及淋巴结转移、远处转移均无关(P>0.05)。肠癌术前贫血组与无贫血组患者Hepcidin及NEO的表达均无区别。肿瘤组织中Hepcidin与NEO的表达具有一定的负相关性,但未达到统计学意义(r=-0.04,P>0.05)。结论:肿瘤组织中Hepcidin的表达与肠癌患者的T分期有关,与其他生物学因素无相关性,NEO与肠癌患者的临床特征无任何相关性;且Hepcidin与NEO的表达无明显相关性。Hepcidin一定程度上可以作为反映肠癌生物学行为的客观指标。肠癌患者术前贫血与肿瘤组织中Hepcidin及NEO的表达无关。
OBJECTIVE: To study the expression of Hepcidin and Neogenin (NEO) related to iron metabolism in patients with colorectal cancer and its relationship with clinical features and anemia. Methods: Immunohistochemistry was used to detect the expression of Hepcidin and NEO in 62 cases of colorectal cancer. The relationship between them and the clinical features and anemia were analyzed. Results: The expression of hepcidin was correlated with T stage (P <0.05), but not with lymph node metastasis and distant metastasis. The expression of NEO had no correlation with T stage, lymph node metastasis and distant metastasis (P> 0.05). There was no difference in the expression of Hepcidin and NEO between patients with preoperative anemia and without anemia. The expression of Hepcidin and NEO in tumor tissue had a certain negative correlation, but did not reach statistical significance (r = -0.04, P> 0.05). Conclusion: The expression of Hepcidin in tumor tissue is related to the T stage of colorectal cancer patients. There is no correlation with other biological factors. There is no correlation between NEO and the clinical features of patients with colorectal cancer. There is no significant correlation between the expression of Hepcidin and NEO. To some extent, Hepcidin can be used as an objective indicator of the biological behavior of colorectal cancer. Preoperative anemia in patients with colorectal cancer and tumor tissue Hepcidin and NEO expression has nothing to do.