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1733年Hales观察到马的血压和脉搏的改变是与呼吸方式相关联而规律变化的。1846年Ludwig发明了记波器从而能观察到狗规律性地吸气时脉搏加快和呼气时脉搏减慢。一个多世纪以来医学生们一直接受着这样的教育,即这种规律发生的心跳不规律性随年龄增长而消失。因为很少生物现象骤然消失,所以在我们看来是由于临床检测呼吸性窦性心律失常(RSA)的方法不精确因而认为它消失了。1963年一个能使受试者的呼吸方式与心率相关联的随意偶联系统的发明,1972年单余弦分析方法的形成才使得这一节律性生物现象的精确定量统计学分析有了可能。本系统大致包括一个脉搏感受器;一个电流鉴频器和计时钟用来计数并记录由脉搏换能器发射的
In 1733 Hales observed that the horse’s blood pressure and pulse changes are regularly related to the pattern of breathing. In 1846 Ludwig invented the recorder so that it could be observed that the dog regularly pulls in to inspiratory pulse and the pulse expiratory slows down. For more than a century, medical students have been taught that the irregular heartbeat of this pattern disappears with age. Because few biological phenomena disappear abruptly, it seems to us that it disappears due to inaccurate methods of clinically detecting respiratory sinus arrhythmia (RSA). The invention of an arbitrary coupling system that correlated the breathing pattern of a subject with heart rate in 1963 resulted in the possibility of an accurate quantitative statistical analysis of this rhythmic biological phenomenon by the 1972 cosine analysis. The system generally includes a pulsatile sensor; a current discriminator and clock for counting and recording the pulse transducers fired