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目的对重症加强护理病房(ICU)抗生素相关性腹泻进行全面分析。方法回顾性分析120例抗生素相关性腹泻患者的临床资料。结果 120例患者中,其中有28例发生腹泻的时间<5 d,占23.33%;48例发生腹泻的时间为5~10 d,占40.00%;44例发生腹泻的时间>10 d,占36.67%;有19例腹泻患者应用抗生素的时间<5 d,感染率为15.83%;69例腹泻患者抗生素使用时间为5~10 d,感染率为57.50%;32例腹泻患者抗生素使用时间>10 d,感染率为26.67%;其中有69例患者为一联用药,感染率为57.50%;18例患者为二联用药,感染率为15.00%;33例患者为三联或者超过三联用药,感染率为27.50%。结论合理应用抗生素可有效降低ICU抗生素相关性腹泻的发生率,对改善患者治疗预后具有非常重要的意义。
Objective To conduct a comprehensive analysis of antibiotic-associated diarrhea in Intensive Care Unit (ICU). Methods The clinical data of 120 patients with antibiotic-associated diarrhea were retrospectively analyzed. Results Among the 120 patients, diarrhea occurred in 28 of 28 cases (23.33%), diarrhea in 48 cases (40.00%), diarrhea in 44 cases (10 days) %. Antibiotics time was less than 5 days in 19 diarrhea patients and the infection rate was 15.83%. The antibiotic use time in 69 diarrhea patients was 5 to 10 days and the infection rate was 57.50%. The antibiotic use time in 32 diarrhea patients was> 10 d , And the infection rate was 26.67%. Among them, 69 patients were combined with one drug, the infection rate was 57.50%; 18 patients were treated in combination with two drugs, the infection rate was 15.00%; 33 patients were triple or over triple therapy, the infection rate was 27.50%. Conclusion The rational use of antibiotics can effectively reduce the incidence of antibiotic-associated diarrhea in ICU, which is of great significance to improve the prognosis of patients.