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目的：探讨慢性阻塞性肺病（ Ｃ Ｏ Ｐ Ｄ） 患者运动中生理死腔量（ Ｖ Ｄ） 及其与潮气量（ Ｖ Ｔ） 比值（ Ｖ Ｄ／ Ｖ Ｔ） 的变化与临床意义。方法：无创性方法测定 Ｃ Ｏ Ｐ Ｄ 和健康对照者静息与运动时潮气末二氧化碳分压（ Ｐｅｔ Ｃ Ｏ２） ，自动计算出 Ｖ Ｄ 及 Ｖ Ｄ／ Ｖ Ｔ 比值。结果： Ｃ Ｏ Ｐ Ｄ 组运动能力与运动中最大通气量（ Ｖ Ｅｍａｘ） 、最大摄氧量（ Ｖ Ｏ２ ｍａｘ） 、最大潮气量（ Ｖ Ｔｍａｘ） 、通气储备量（ Ｂ Ｒ）均较对照组低。两组 Ｖ Ｄ 运动后均显著增高，组间运动前与运动后差异均无显著性； Ｖ Ｄ／ Ｖ Ｔ 值运动后均显著降低，但 Ｃ Ｏ Ｐ Ｄ组降低程度较小，运动后显著高于对照组。运动后动脉血ｐ Ｈ 值明显下降。结论： Ｃ Ｏ Ｐ Ｄ 缓解期患者运动中 Ｖ Ｄ 变化与健康对照组差异无显著性， Ｖ Ｄ／ Ｖ Ｔ 比值的异常主要由 Ｖ Ｔｍａｘ 增加受限引起。
Objective: To investigate the changes and clinical significance of physiological dead space (V D) and the ratio of tidal volume (V T / V T) in patients with chronic obstructive pulmonary disease (COPD). METHODS: Noninvasive method was used to determine the ratio of V D and V D / V T between Pet O 2 and C O P D at rest and during exercise. Results: The exercise capacity and V Emax, V O2 max, V Tmax and B R in C O P D group were lower than those in control group . V D after exercise increased significantly in both groups, with no significant difference between before exercise and after exercise. V D / V T decreased significantly after exercise, but decreased less in C O P D group and significantly higher after exercise In the control group. Postoperative arterial blood p H decreased significantly. CONCLUSION: There is no significant difference in V D between exercise and exercise in C O P D remission patients. The V D / V T abnormality is mainly caused by the limited increase of V T max.