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为了评价硝酸盐耐药性形成的可能机制,我们对35个有严重慢性心衰的病人用硝酸甘油进行了长时间(48小时)持续的或间断的(每滴注12小时就间隔12小时)静脉滴注(每分钟每公斤体重6.4ug)。所有的病人,静点的硝酸甘油立即产生了血液动力学的疗效,但这种疗效在持续用药48小时后就明显减弱。这种衰减伴有对口服硝酸甘油的交叉耐药性以及心率、血浆肾素活性和体重的增加。相反,用硝酸甘油间断静点治疗却
To evaluate the possible mechanism of nitrate resistance formation, we administered nitroglycerin to 35 patients with severe chronic heart failure for a prolonged period of time (48 hours) or intermittent (12 hours apart for each 12-hour instillation) Intravenous infusion (6.4ug / kg body weight per minute). All patients, intravenous nitroglycerin immediately produce a hemodynamic efficacy, but this effect was significantly reduced 48 hours after continuous medication. This attenuation is accompanied by cross-resistance to oral nitroglycerin and an increase in heart rate, plasma renin activity, and body weight. Instead, treat with nitroglycerin intermittently