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目的探讨冠心病患者血清中MMP-12的表达情况。方法选取90例行冠状动脉造影的患者，采用ELISA检测其血清中MMP-12的含量。根据冠心病临床分型分为稳定性心绞痛、急性冠脉综合征和冠心病合并2型糖尿病，以CA正常为对照。结果 ACS及CHD+DM组血清MMP-12水平高于CA组及SAP组(<0.05)。结论冠心病患者血清中MMP-12水平增高与斑块的不稳定有关；2型糖尿病可增加冠心病患者血清MMP-12的水平。“,”Objective To explore the serum MMP-12 in patients with CHD.Methods Serum samples were obtained from 90 patients,having normal coronary arteries as a control group.The level of MMP-12 was analyzed by ELISA.According to clinical classification were divided into SAP,ACS and CHD+DM.Results Serum MMP-12 were markedly increased in ACS and CHD+DM group compared with control and SAP group( <0.05).Conclusion The high MMP-12 with CHD was suggesting that it maybe related to the stability of coronary plaque.Type 2 diabetes significantly increased the levels of MMP-12 from patients with CHD.