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本文应用放射免疫方法(RIA)研究了甲亢组和甲减组及正常对照组血清β_2微球蛋白含量的变化。结果显示:甲亢组β_2-MG水平显著高于正常对照组与甲减组(P<0.01),而甲减组β_2MG水平显著低于正常对照组(P<0.01),且β_2-MG水平与T_3、T_4水平无线性相关关系(P>0.05)。结果提示,甲亢与甲减患者β_2-MG水平的变化,可能与机体免疫功能紊乱、细胞代谢的失调有关。
In this paper, radioimmunoassay (RIA) was used to study the changes of serum β_2 microglobulin in hyperthyroidism group, hypothyroidism group and normal control group. The results showed that the level of β_2-MG in hyperthyroidism group was significantly higher than that in normal control group and hypothyroidism group (P <0.01), while the level of β_2MG in hypothyroidism group was significantly lower than that in normal control group (P <0.01) , T_4 level of non-linear correlation (P> 0.05). The results suggest that the changes of β_2-MG in patients with hyperthyroidism and hypothyroidism may be related to immune dysfunction and dysregulation of cell metabolism.