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本文采用玻璃微电极细胞内记录技术，研究了培龄０—１４０ｄ新生ＳＤ大鼠下丘脑神经细胞电生理学特征的增龄性变化。以神经突起的生长速度为指标，将细胞体外存活过程分为三期，即恢复期、生长期、衰老期。发现，神经细胞膜时间常数及膜电容于生长期达最大值，而在衰老期显著减小（Ｐ＜０．０５，Ｐ＜０．０１）。恢复期膜阻抗最高，生长期显著下降（Ｐ＜０．０１），但衰老期变化不显著。神经细胞可产生单个或多个诱发放电，其静息电位约－３０－－６０ｍＶ，并呈增龄性增高（Ｐ＜０．０５）。可见，培养的下丘脑神经细胞膜电学特征可表现出一定的衰老性变化。
In this study, we used glass microelectrode intracellular recording technology to study the age-related changes of electrophysiological characteristics of hypothalamic neurons in 0-140 d neonatal SD rats. Neurite outgrowth rate as an indicator, the cell survival process in vitro is divided into three phases, namely, recovery, growth and aging. It was found that the time constant of membrane and membrane capacitance reached the maximum at the growth phase and decreased significantly at senescence (P <0.05, P <0.01). During the recovery period, the membrane impedance was the highest and the growth period was significantly decreased (P <0.01), but the change of senescence period was not significant. Nerve cells can produce single or multiple evoked discharges, the resting potential of about -30 - 60mV, and increased age (P <0.05). Visible, cultured electrical characteristics of the hypothalamus neurons membrane can show some changes in aging.