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目的探讨托吡酯联合氟桂利嗪治疗偏头痛的临床疗效,总结临床经验。方法将2008年6月至2012年10月本科收治的94例患者随机分为A组、B组、C组,分别给予托吡酯联合氟桂利嗪、单纯托吡酯、单纯氟桂利嗪治疗,记录并作回顾性分析。结果治疗后A组、B组、C组患者的总有效率分为为91.18%、70.00%、66.67%,A组总有效率优于B组及C组且差异具有统计学意义(P<0.05)。结论托吡酯联合氟桂利嗪治疗偏头痛的临床疗效确切,值得临床上进一步研究推广。
Objective To investigate the clinical efficacy of topiramate plus flunarizine in the treatment of migraine and to summarize the clinical experience. Methods 94 patients admitted from June 2008 to October 2012 were randomly divided into group A, group B and group C, and were given topiramate combined with flunarizine, topiramate alone, flunarizine alone, and recorded For retrospective analysis. Results After treatment, the total effective rates of patients in group A, group B and group C were 91.18%, 70.00% and 66.67% respectively. The total effective rate in group A was better than that in group B and C (P <0.05) ). Conclusion Topiramate combined with flunarizine for the treatment of migraine has an exact clinical curative effect and deserves to be further popularized in clinic.