论文部分内容阅读
目的 研究Ⅰ型重症肌无力 (MG)患者的呼吸功能状况与健康人的差异 ,并对比研究应用抗胆碱酯酶药后患者肺功能状况的改变。方法 4 6例MG患人和 5 0例健康人 ,分别行肺功能 (肺活量、第 1秒用力呼气量、用力肺活量、1秒率、吸气量、最大呼吸流量容积曲线、最大通气量、残气容积 )、和血气分析 (pH、PaCO2 、PaO2 )和血氧饱和度 (SaO2 )检测。MG患者在检测肺功能之后平静休息 30min以上 ,肌注抗胆碱酯酶药 (新斯的明 1mg)后 30min再次检测肺功能。结果 (1)MG患者肺功能状况显著低于健康人 ,但其动脉血气水平和SaO2 与健康人比较无显著性差异 ;(2 )MG患者在应用新斯的明之后肺功能状况有明显的改善。结论 MG患者尽管平静状态下无呼吸困难 ,但呼吸功能状况已有潜在性损害 ,当有肺部感染、需要麻醉手术治疗等情况时 ,应密切注意其肺功能状况
Objective To study the differences of respiratory function between healthy people and patients with type Ⅰ myasthenia gravis (MG), and to compare the changes of lung function status after applying anticholinesterase drugs. Methods Twenty-four patients with MG and 50 healthy subjects were enrolled in this study. Their lung function (vital capacity, forced expiratory volume in 1 second, forced vital capacity, rate in 1 second, inspiratory capacity, maximum respiratory volume volume curve, maximum ventilation, Residual volume), and blood gas analysis (pH, PaCO2, PaO2) and oxygen saturation (SaO2) detection. MG patients in the detection of lung function after a quiet rest more than 30min, intramuscular injection of anti-cholinesterase drugs (neostigmine 1mg) again after 30min lung function test. Results (1) The lung function of patients with MG was significantly lower than that of healthy people, but the arterial blood gas levels and SaO2 had no significant difference compared with healthy people. (2) The lung function of patients with MG was significantly improved after neostigmine . Conclusion Although patients with MG have no dyspnea in calm state, the respiratory function status has been potentially damaged. When pulmonary infection is needed and anesthetic surgery is needed, pay close attention to their pulmonary function status