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目的 利用动物模型反向证明骺组织生长潜能治疗先天性脊柱侧弯的可能性。方法 对 16只离乳的幼犬分实验组和两个对照组 ,行脊柱一侧的前后方骺切除及骨融合术 ,经过喂养 14周后 ,观察脊柱能否发生侧弯、侧弯程度以及畸形与年龄的关系。结果 16只动物中 13只动物达到预期效果 ,实验组动物脊柱畸形明显 ,并随时间进行性加重。第 14周时 ,实验组动物的平均Cobb角为37.0°± 6 .4 8° ;实验组与两个同期的对照组相比差异有显著性意义 (P1=0 .0 0 0 4 9,P2 =0 .0 0 0 2 7)。结论 幼犬实施前后路联合一侧骺切除和局部融合术可以造成脊柱侧弯。借助这种生长阻滞方法矫治婴幼儿和学前期先天性脊柱侧弯是可能的
Objective To reverse the potential of epiphyseal tissue growth potential to treat congenital scoliosis by animal model. Methods Sixteen puppies were divided into experimental group and two control groups. The anteroposterior epiphysis and osteosynthesis were performed on one side of the spine. After 14 weeks of feeding, the spine was examined for scoliosis, Relationship between deformity and age. Results Thirteen animals of 16 animals achieved the expected results. The animals in the experimental group had obvious spinal deformities and progressed with time. At week 14, the mean Cobb angle of the experimental animals was 37.0 ° ± 6.48 °. There was significant difference between the experimental group and the two control groups (P1 = 0.0604 9, P2 = 0 .0 0 0 2 7). Conclusions Puppies may be associated with scoliosis by anterior and posterior appendectomy and local fusion. It is possible to treat infants and preschool congenital scoliosis with this growth arrest method